Additional file 1 of A serological biomarker of type I collagen degradation is related to a more severe, high neutrophilic, obese asthma subtype
datasetposted on 14.04.2022, 03:34 authored by Sarah Rank Rønnow, Jannie Marie Bülow Sand, Line Mærsk Staunstrup, Thomas Bahmer, Michael Wegmann, Lars Lunding, Janette Burgess, Klaus Rabe, Grith Lykke Sorensen, Oliver Fuchs, Erika V. Mutius, Gesine Hansen, Matthias Volkmar Kopp, Morten Karsdal, Diana Julie Leeming, Markus Weckmann
Additional file 1: Table e1. Basic demographics of the PERF cohort. E-Figure1. A) Correlation betweenserum C1M level and blood neutrophils. Data were analysed using spearman’scorrelation (r = 0.214). B) Patients were stratified into highversus low percentage blood neutrophils levels based on the median. C1M wassignificantly increased in patients with high neutrophil levels (n = 122) compared to low (n = 128) (p = 0.0130). C) C1Mwas significantly increased in obese (BMI>30) patients (n = 60) compared to normal-weight (BMI<25) patients (n = 85) (p < 0.0001). D) Obeseasthmatics with high blood neutrophils (n= 29) had a significant increase in C1M compared to normal-weight asthmaticswith low blood neutrophils (n = 39) (p < 0.0001). Data arepresented as a Tukey box plot and analyzed using the Mann-Whitney test.Asterisks indicate statistically significance: *p < 0.05, ****p < 0.0001.
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body mass indexlow neutrophil levelsdegradation causing fragmentschronic inflammatory diseaseresults serum c1mage asthma studyhigh neutrophil levelsincreased c1m levelssignificantly increasedneutrophil infiltrationheterogeneous diseaseblood neutrophilhigh neutrophilicmethods c1mc1m comparedvivo modeluncontrolled asthmatrial registrationsignificantly elevatedsignificant increaseserological biomarkeroverall inflammationnct02419274 ).matrix metalloproteinaseshighly desirableextracellular matrixdirect therapydata suggestcontrolled asthmacollagen degradationadult participants283 ).233 ),047 ).0277 ).0005 ).