posted on 2021-01-08, 04:50authored byMonica del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen, Ilkka Seppälä, Weihua Zhang, Kirstin Mittelstraß, Simone Wahl, Pamela R. Matias-Garcia, Holger Prokisch, Sacha Horn, Thomas Meitinger, Luis R. Serrano-Garcia, Sylvain Sebert, Olli Raitakari, Marie Loh, Wolfgang Rathmann, Martina Müller-Nurasyid, Christian Herder, Michael Roden, Mikko Hurme, Marjo-Riitta Jarvelin, Mika Ala-Korpela, Jaspal S. Kooner, Annette Peters, Terho Lehtimäki, John C. Chambers, Christian Gieger, Johannes Kettunen, Melanie Waldenberger
Additional file 15: Table S11. Results of the associations between CpG sites and expression of transcripts of genes codifying for enzymes or proteins directly involved with lipoprotein metabolism. Results are shown for those pairs passing a false discovery rate (Benjamini-Hochberg) threshold of FDR < 0.05. Presented are the CpG sites and expression probe IDs; the annotated genes of the CpG site and expression probe; the chromosomes of the CpG site and expression probe; the chromosomal location of the CpG site; the distance between the CpG site and expression probe (where Inf indicates they are on different chromosomes); the coefficient (Coef) of the CpG site from the regression analysis; standard error of the coefficient (SE); p value of the coefficient (P); Bonferroni-corrected p value (Bonf_P); FDR-corrected p value (FDR); number of observations for the model (N); and whether the association is significant at Bonferroni-corrected threshold (based on 12 CpGs × 62 expression probes: p < 0.05/(12 * 62) =6.7e−5 ). All coefficients are change in log2- transformed expression intensity per unit increase in methylation (beta value on 0–1 scale).
Funding
Bundesministerium für Bildung und Forschung (DE) Munich Center of Health Sciences Deutsche Forschungsgemeinschaft (DE) Bundesministerium für Bildung und Forschung Deutsches Zentrum für Diabetes Forschung National Institute for Health Research British Heart Foundation Medical Research Council Welcome Trust NIHR Official Development Assistance European Union FP7 H2020 programs Academy of Finland Social Insurance Institution of Finland Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals Diabetes Research Foundation of Finnish Diabetes Association EU Horizon 2020 European Research Council European Union’s Horizon 2020 research and innovation programme Academy of Finland (FI) Joint Programming Initiative A healthy diet for a healthy life () Consejo Nacional de Ciencia y Tecnología-México Sigrid Juséliuksen Säätiö Singapore Ministry of Health’s National Medical Research Council