Additional file 14 of Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations
posted on 2021-03-25, 08:38authored byJ. Pei, M. Schuldt, E. Nagyova, Z. Gu, S. el Bouhaddani, L. Yiangou, M. Jansen, J. J. A. Calis, L. M. Dorsch, C. Snijders Blok, N. A. M. van den Dungen, N. Lansu, B. J. Boukens, I. R. Efimov, M. Michels, M. C. Verhaar, R. de Weger, A. Vink, F. G. van Steenbeek, A. F. Baas, R. P. Davis, H. W. Uh, D. W. D. Kuster, C. Cheng, M. Mokry, J. van der Velden, F. W. Asselbergs, M. Harakalova
Additional file 14: Table S6 (A) The overlapping genes between differentially expressed genes using DESeq2 and the top 2,000 genes that discriminate HCM from control hearts using O2PLS. (B) Enriched GO terms and pathways by the overlapping genes. (C) Enriched GO terms and pathways by a subset of the overlapping genes, which showed the same changing direction at their protein levels in HCM hearts when compared with controls
Funding
The Netherlands Foundation for Cardiovascular Excellence NWO VENI grant NWO VIDI grant ZonMW-NWO VICI grant Erasmus MC fellowship grant RM fellowship grant of the UMC Utrecht Wilhelmina Children’s Hospital research funding Netherlands Cardiovascular Research Initiative: An initiative with the support of the Dutch Heart Foundation UCL Hospitals NIHR Biomedical Research Centre H2020 European Research Council