13073_2021_967_MOESM10_ESM.xlsx (47.2 kB)
Additional file 10 of Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus
dataset
posted on 2021-10-11, 03:14 authored by Marcus M. Soliai, Atsushi Kato, Britney A. Helling, Catherine T. Stanhope, James E. Norton, Katherine A. Naughton, Aiko I. Klinger, Emma E. Thompson, Selene M. Clay, Soyeon Kim, Juan C. Celedón, James E. Gern, Daniel J. Jackson, Matthew C. Altman, Robert C. Kern, Bruce K. Tan, Robert P. Schleimer, Dan L. Nicolae, Jayant M. Pinto, Carole OberAdditional file 10: Tables showing enrichment and colocalization results from this study. Table S1: Interaction model results for genotype x atopy and genotype x steroid use for eQTLs and meQTLs. Table S2: Enrichment estimates of eQTLs for TAGC asthma GWAS SNPs from six tissues. No P-values were significant after FDR correction. Table S3: Enrichment estimates of eQTLs for adult onset asthma GWAS SNPs from six tissues. No P-values were significant after FDR correction. Table S4: moloc results for molecular QTL-GWAS pairs and triplets. Table S5: Asthma GWAS risk allele effects on gene expression and DNA methylation.
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National Institutes of Health Ernest S. Bazley Charitable Fund
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study provides evidencedna methylation dataepigenetic response mechanismsadult onset asthmamodulate genetic effects21 asthma locuswide association studiesused mendelian randomizationtreated upper aecsassociated gwas snpsspecific genetic mechanismspecific functional annotationschildhood onset asthmaasthma colocalized locimapped cis expressionaec molecular qtlsasthma risk variantswide geneticchildhood onsetfunctional effectsresults asthmavariants associatedtslp locusgene expressionethnic gwasepigenetic responsesepidemiological studiesspecific informationvariants discoveredtreatment conditionpromoting pathogenmediated transcriptionalincluding qtlsimmune diseasesidentified thousandshealthy participantsenvironmental factorsculture modelcomplex diseasescell typesbayesian testassess transcriptionalallergic diseaseaec qtls38 ).
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