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Acute stress induces long-term metabolic, functional and structural remodeling of the heart
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posted on 2023-06-29, 07:02 authored by Thulaciga Yoganathan, Mailyn Perez-Liva, Daniel Balvay, Morgane Le Gall, Alice Lallemand, Anaïs Certain, Gwennhael Autret, Yasmine Mokrani, François Guillonneau, Johanna Bruce, Vincent T. Nguyen, Umit Gencer, Alain Schmitt, Franck Lager, Thomas Guilbert, Patrick Bruneval, José Vilar, Nawal Maissa, Elie Mousseaux, Thomas Viel, Gilles Renault, Nadjia Kachenoura, Bertrand TavitianTakotsubo syndrome, a stress-induced cardiomyopathy mimicking an acute coronary syndrome but formerly considered a benign reversible disease, increases the risk of heart failure and cardiac death. Here, the authors show that the function and structure of the heart engage in a continuous deterioration after acute stress and link this snowball effect to deviated control of cardiac metabolism.
