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MOESM8 of Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells

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posted on 2019-10-11, 05:37 authored by Fujun Li, Lixia Miao, Teng Xue, Hao Qin, Santanu Mondal, Paul Thompson, Scott Coonrod, Xiaoqiu Liu, Xuesen Zhang
Additional file 8. Figure S8. CCK8 assay showing passively activating mTOR by MHY1485 reversed the inhibiting effect of docetaxel on viability of PAD2 knockdown (a) or miR-125b-5p overexpression (b) MCF7/TamR cells. shCon: shRNA control MCF7/TamR cells; shPAD2: PAD2 knockdown cells; EV con: Empty vector pQXCIP overexpression MCF7/TamR cells; miR-125b-5p: miR-125b-5p overexpression cells; Doc: docetaxel; PBS was used as a control. (*P < 0.05).

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National Key Research and Development Program of China

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    Journal of Experimental & Clinical Cancer Research

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    Breast cancerTamoxifen-resistancePAD2Docetaxel

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