Springer Nature
Browse
12964_2019_444_MOESM8_ESM.docx (72.74 kB)

MOESM8 of Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation

Download (72.74 kB)
journal contribution
posted on 2019-10-18, 09:27 authored by Yi-Heng Hao, M. Lafita-Navarro, Lauren Zacharias, Nofit Borenstein-Auerbach, Min Kim, Spencer Barnes, Jiwoong Kim, Jerry Shay, Ralph DeBerardinis, Maralice Conacci-Sorrell
Additional file 8: Figure S8. (A) Heatmap comparing the metabolic profile of myc−/− cell reconstituted with MYC and transfected with either control siRNA or siRNA for LEF1. (B) Metabolites and metabolic pathways altered by LEF1 silencing. (C) Diagram of β-oxidation with metabolites affected by LEF1 knockdown in MYC-expressing cells and their corresponding enzymes.

Funding

Cancer Prevention and Research Institute of Texas

History

Usage metrics

    Cell Communication and Signaling

    Categories

    Keywords

    MYCWNT/β-catenin pathwayLEF1Colon cancerTumorigenesisMetabolismPPARδACAD9Proliferation

    Licence

    CC BY + CC0

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC