13058_2020_1245_MOESM7_ESM.pdf (9.21 MB)
MOESM7 of p66ShcA functions as a contextual promoter of breast cancer metastasis
journal contribution
posted on 2020-01-16, 04:56 authored by Kyle Lewis, Alex Kiepas, Jesse Hudson, Julien Senecal, Jacqueline Ha, Elena Voorand, Matthew Annis, Valerie Sabourin, Ryuhjin Ahn, Rachel Selva, Sébastien Tabariès, Brian Hsu, Matthew Siegel, Matthew Dankner, Eduardo Canedo, Mathieu Lajoie, Ian Watson, Claire Brown, Peter Siegel, Josie Ursini-SiegelAdditional file 7: Figure S7. A p66ShcA-induced epithelial to mesenchymal transition is dispensable for metastatic progression in a luminal breast cancer model. Immunohistochemical analysis of vector control (VC), p66ShcA-WT and p66ShcA-S36A overexpressing NIC mammary tumors using (A) E-Cadherin and (B) Vimentin-specific antibodies. The data is shown as average tumor volume (mm3) ± SEM (n = 7 tumors/group). Representative images are shown. Statistical analysis was performed using a one-way Anova with a Tukey’s multiple comparisons test (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001).
