13099_2019_293_MOESM6_ESM.tif (2.76 MB)

MOESM6 of NMR metabolomics reveals effects of Cryptosporidium infections on host cell metabolome

Download (2.76 MB)
posted on 03.04.2019 by Christopher Miller, Charalampos Panagos, William Mosedale, Martin Kváč, Mark Howard, Anastasios Tsaousis
Additional file 6: Figure S6. Metabolic pathways detected in mouse model NMR samples. a Data analysed by MetaboAnalyst 3.0, utilising all compounds which displayed some degree of change as a result of infection, produced a graph of pathways most heavily impacted (x axis) and pathways containing the most amount of the given compounds (pathway impact: y-axis), with statistical significance of the predicted pathways increasing as the colour ranges from yellow (low) to red (high). Six pathways were chosen to be of particular interest by their position on the graph, with metabolites present in the experimental samples highlighted in red, including: b pentose and glucuronate interconversions, valine, c valine, leucine and isoleucine biosynthesis, d glycine serine and threonine metabolism, e taurine and hypotaurine metabolism, f galactose metabolism and g starch and sucrose metabolism.


Biotechnology and Biological Sciences Research Council