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MOESM6 of Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells

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posted on 2019-10-11, 05:37 authored by Fujun Li, Lixia Miao, Teng Xue, Hao Qin, Santanu Mondal, Paul Thompson, Scott Coonrod, Xiaoqiu Liu, Xuesen Zhang
Additional file 6. Figure S6. Western blot analysis of the PAD2 knockdown (a) or miR-125b-5p overexpression (b) further decreased the levels of phosphorylated Akt and Rps6 phosphorylation in MCF7/TamR cells treated with 0.1 ÎźM docetaxel. GAPDH served as loading control. shCon: shRNA control MCF7/TamR cells; shPAD2: PAD2 knockdown cells; EV con: Empty vector pQXCIP overexpression MCF7/TamR cells; miR-125b-5p: miR-125b-5p overexpression; Doc: docetaxel; PBS was used as a control.

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