40246_2019_238_MOESM6_ESM.tif (2.36 MB)
MOESM6 of EFTUD2 gene deficiency disrupts osteoblast maturation and inhibits chondrocyte differentiation via activation of the p53 signaling pathway
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posted on 2019-12-06, 04:44 authored by Jing Wu, Yi Yang, You He, Qiang Li, Xu Wang, Chengjun Sun, Lishun Wang, Yu An, Feihong LuoAdditional file 6: Figure S5. Differentially expressed genes identified through RNA-Seq analysis. A: Correlation analysis between HCO cells transfected with shNT (Group1) or sh2 lentivirus (Group2), which showed a close relationship between the two groups. B: Genes of Group 1 and Group2 are located on all of the chromosomes. C: There were 6 genes involved in the P53 pathway, including P21, FAS, STEAP3, CASP3, SESN1 and THBS. All of these genes showed elevated expression, except THBS, which was downregulated.