MOESM5 of The distributions of protein coding genes within chromatin domains in relation to human disease

Additional file 5: Figure S4. Fraction of genes for HK and non-HK genes associated with disease (ordinates) depending on the number of genes contained within the TADs (n; abscissas); the numbers have been aggregated for n ≥ 6. The lower the number of genes inside the TAD the higher fraction of the genes associated with disease: a. HK genes; a p-value = 3.6 × 10−5 from a Chi-square test, comparing the number of genes associated and non-associated with disease for the six TAD categories, was obtained. The green dotted line represents the genome-wide fraction of HK genes associated with disease (0.309). b. non-HK genes; a p-value = 1.2 × 10−43 from a Chi-square test has been obtained. The green dotted line represents the genome-wide fraction of non-HK genes associated with disease (0.366).