MOESM5 of Hypoxia and therapeutic treatment of EV-A71 with an immune modulator TLR7 agonist in a new immunocompetent mouse model

Additional file 5: Figure S5. Oral intake or ip injection with a TLR7 agonist GS-9620 after virus inoculation efficiently rescued mice from paralysis and death. a Upper panel: A schematic diagram of GS-9620 treatment via an i.p. route after EV-A71 infection. Mice of different experimental groups received one shot of GS-9620 at dpi = 1 or dpi = 4 (disease onset). Lower panel: Clinical scores were significantly lower in mice receiving timely treatment of GS-9620 at dpi = 1. Red, EV-A71-infected mice with no drug treatment; Blue, 4.5 μg GS-9620 per g of body weight at dpi = 1; Green, 3.0 μg GS-9620 per g of body weight at dpi = 1. b Upper panel: A schematic diagram of GS-9620 treatment via an oral route after EV-A71 infection. Lower panel: Three experimental groups of mice received GS-9620 at three different doses (0, 3.0 and 4.5 μg /g of mouse) at dpi = 1. Significant reduction in clinical score was observed in the groups treated with GS-9620.