MOESM5 of Carvacrol ameliorates acute campylobacteriosis in a clinical murine infection model
2020-01-09T05:47:27Z (GMT) by
Additional file 5: Figure S5. Ileal pro-inflammatory mediator secretion in carvacrol treated mice following C. jejuni infection. Starting 4 days prior peroral C. jejuni infection on days 0 and 1, secondary abiotic IL-10−/− mice were treated with synthetic carvacrol (CARVA; white boxes) or placebo (PLC; grey boxes) via the drinking water. (A) IFN-γ and (B) TNF concentrations were measured in supernatants of ileal ex vivo biopsies derived at day 6 post-infection. Naive mice served as uninfected controls. The total range, significance levels (p-values) determined by the Mann–Whitney U test and numbers of analyzed animals (in parentheses) are indicated. Data were pooled from four independent experiments.