MOESM4 of Vascular-targeted TNFα and IFNγ inhibits orthotopic colorectal tumor growth

Additional file 4: Fig. S4. Antitumor activity of TCP-1/TNFα combined with TCP-1/IFNγ compared with single treatment and histological examination of combined treatment. (A) Picture of the tumors after 7 day treatment (n ≥ 3 per group). (B) Tumor weight at the end of experiment. Combined treatment (TCP-1/TNFα 1 μg/mouse and TCP-1/IFNγ 5 μg/mouse) significantly inhibited tumor growth than single treatment. (C) Body weight change of TCP-1/TNFα and TCP-1/IFNγ combined treatment group (TCP-1/TNFα 0.5 μg/mouse and TCP-1/IFNγ 2.5 μg/mouse) compared with control group. (D) Sections from TCP-1/TNFα and TCP-1/IFNγ combined treatment group (TCP-1/TNFα 0.5 μg/mouse and TCP-1/IFNγ 2.5 μg/mouse) were subsequently stained by Harris hematoxylin solution and eosin Y solution (H & E). There were no detectable pathological changes in the control and treatment group.