MOESM4 of Pcdhβ deficiency affects hippocampal CA1 ensemble activity and contextual fear discrimination
2020-01-21T05:13:47Z (GMT) by
Additional file 4: Figure S4. Pcdhβ deficiency does not affect the number of ensembles activated in the home cage and during novel context exploration (related to Fig. 2). (a) Schematic diagram of the non-negative matrix factorization (NMF) analysis. (b) Representative image of an ensemble extracted with NMF. Red arrows (left) indicate the cells contributing to this ensemble. Red dots (right) indicate the times at which the ensemble was activated. (c–d) Normalized number of ensembles extracted in each session (panel c: F(4, 3) = 1.907, P = 0.6229; t7 = 1.648, P = 0.1434; panel d: F(4, 3) = 1.086, P = 0.9856; t7 = 0.2852, P = 0.7837; unpaired t-test; n = 5 Wt mice, 4 Δβ mice). Data are means ± SEMs.