MOESM4 of Dapagliflozin improves left ventricular remodeling and aorta sympathetic tone in a pig model of heart failure with preserved ejection fraction

Additional file 4: Fig. S1. Dapagliflozin had no significant effect on cardiomyocyte CSA or LA fibrosis in HFpEF pigs. The cardiomyocyte CSA of the LV and LA was calculated (A and B). Representative images of Masson’s trichrome staining of the LA posterior wall are shown (C). The area percentages of LA fibrosis were calculated (D). Values are expressed as the mean ± SD. n = 10 pigs per group. Statistical analyses were performed by one-way ANOVA followed by the Bonferroni post hoc test. *p < 0.05 vs. the Normal group.