12936_2017_1845_MOESM5_ESM.pdf (392.93 kB)
MOESM4 of Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia
journal contribution
posted on 2017-05-12, 05:00 authored by Angana Mukherjee, Selina Bopp, Pamela Magistrado, Wesley Wong, Rachel Daniels, Allison Demas, Stephen Schaffner, Chanaki Amaratunga, Pharath Lim, Mehul Dhorda, Olivo Miotto, Charles Woodrow, Elizabeth Ashley, Arjen Dondorp, Nicholas White, Dyann Wirth, Rick Fairhurst, Sarah VolkmanAdditional file 5. Association between percent survival RSA0â3h and clearance time. Correlation between clearance time on the x-axis and percent survival RSA0â3h on the y-axis. Each dot represents an isolate. Samples represented by color were used for in vitro drug testing and for pfmdr1 copy number variation determinationâgreen for ART sensitive; blue for discordant; and red for ART resistant parasites. The grey dot marks the isolate with an E270K mutation. The dotted lines represent the cut off used to discriminate between resistant and sensitive parasites (1% for RSA0â3h, 4 or 5% for clearance).
