MOESM4 of A multi-breed reference panel and additional rare variants maximize imputation accuracy in cattle

Additional file 4: Figure S2. Schematic representation of “one-round” vs. “two-round” imputation. Description: Dotted lines represent imputation. In “one-round” imputation (a), HD and F250 reference samples are cross-imputed to create a partially imputed composite reference panel (1). This is followed by a single round of imputation of low-density genotypes using the CR panel (2). For “two-round” imputation (b), two rounds of imputation occur: first from low-density to HD (1) and then from HD to 850 K (2).