MOESM3 of Inulin-type fructans supplementation improves glycemic control for the prediabetes and type 2 diabetes populations: results from a GRADE-assessed systematic review and dose–response meta-analysis of 33 randomized controlled trials

Additional file 3: Figure S2. Non-linear dose-response analysis between ITF supplement (dose, duration, and total dosage) and glycemic parameters (FBG, HbA1c, FINS, HOMA-IR) levels in the total population. The dose-response analysis was conducted using the nonlinear robust error meta-regression (REMR) model, which is mainly based on the inverse variance-weighted least squares regression and cluster robust error variances for dealing with the synthesis of correlated dose-response data from different studies. The solid line represents weighted mean difference and the dotted lines represent the 95% confidence intervals (CIs). Abbreviations: FBG, fasting blood glucose; FINS, fasting insulin; HbA1c, glycosylated hemoglobin; HOMA-IR, homeostasis model assessment-insulin resistance; T2DM, type2 diabetes mellitus.