MOESM3 of Hypoxia and therapeutic treatment of EV-A71 with an immune modulator TLR7 agonist in a new immunocompetent mouse model

Additional file 3: Figure S3. Treatment with neutralizing antibody against IFNAR enhanced VP1 signals in the thoracic spinal cord. Thoracic vertebrae can be divided into 4 segments. In control mice without IFNAR antibody treatment, VP1 protein signals in the spinal cord were weak, and limited to only a small segment 2 of the thoracic vertebrae. In contrast, in mice treated with anti-IFNAR antibody, VP1 protein signals in thoracic segment 2 were stronger, and more wide-spread to other segments of cervical vertebrae (Fig. 4d).