MOESM3 of Atrial fibrillation and its arrhythmogenesis associated with insulin resistance

Additional file 3: Figure S2. Effects of KN-92 in atrial fibrillation (AF) induced by short pacing cycle length (PCL) in high-fat (HFa) and high-fructose/cholesterol (HFr) diet-fed rats. The figure shows representative optical membrane voltage (AP) and calcium transient (CaT), action potential duration at 80% repolarization (APD80), and CaT duration at 80% repolarization (CaTD80) maps of right atrial appendages (RAAs) in (A) one HFr diet-fed rat and (B) one HFa diet-fed rat at short PCLs before and after application of KN-92 (1 µmol/L), respectively. None of the HFr or HFa rat atria (n = 5 for each group) exhibited decrease or increase in AF duration after KN-92 infusion.