MOESM2 of The SMAC mimetic LCL-161 selectively targets JAK2V617F mutant cells
2020-01-03T04:55:32Z (GMT) by
Additional file 2: Figure S2. Expression levels of cIAP1/2 or XIAP do not influence sensitivity of human cell lines to LCL-161. Western blot of K562 (BCR-ABL mutant) and HEL (JAK2V617F) cells treated with 10 nM LCL-161 for 2 h before protein isolation. LCL-161 reduces expression of cIAP1 and cIAP2 in both cell lines as expected. XIAP expression was unaffected by LCL-161.