MOESM1 of The SMAC mimetic LCL-161 selectively targets JAK2V617F mutant cells
2020-01-03T04:55:31Z (GMT) by
Additional file 1: Figure S1. NFĸB inhibitor protects JAK2V617F mutant cells from killing by LCL-161 in the absence of TNFα and empty vector cells from killing by LCL-161 in the presence of TNFα. L929 cell transduced with empty vector or JAK2V617F were exposed to LCL-161, either in the presence or absence of 1 ng/ml hTNFα and 1nM QNZ. The concentration of LCL-161 used without TNFα was 1.5 µM and with TNFα was 12.5 nM. After 48 h of culture a resazurin based cell viability assay was performed.