Additional file 1 of Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers

Additional file 1 : Table S1. Studies and samples included in the prospective cohort of BRCA1 and BRCA2 mutation carriers. Table S2. Distributions of dates of breast cancer diagnosis, DNA test and start of follow-up in the prospective cohort. Table S3. Characteristics of reported Risk-Reducing Salpingo-oophorectomy. Table S4. Characteristics of cohort of BRCA1 and BRCA2 mutation carriers. Table S5. Association between RRSO and breast cancer by menopausal status. Table S6. Association between RRSO and breast cancer (sensitivity analysis with RRSO status changing at the age at the questionnaire with information on RRSO status changes (all studies except HEBON)). Table S7. Association between RRSO and breast cancer (sensitivity analysis dropping individuals with missing information at baseline). Table S8. Association between RRSO and breast cancer among BRCA1 and BRCA2 mutation carriers (sensitivity analysis excluding women with RRSO before baseline). Table S9. Association between family history of breast cancer and family history of ovarian cancer and RRSO uptake. Table S10. Association between parity, age at first birth, and body mass index and RRSO uptake. Table S11. Association between RRSO and breast cancer adjusting for Body Mass Index, family history of breast cancer, family history of ovarian cancer, parity and age at first birth. Table S12. Hormone replacement therapy use among women in the cohort. Table S13. Association between RRSO and breast cancer among women not exposed to hormone replacement therapy. Table S14. Association between RRSO and breast cancer (excluding kConFab/BCFR). Table S15. Association between natural menopause and breast cancer (censoring at RRSO). Ethics Committee Approvals