MOESM1 of Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer’s disease: a longitudinal multimodal in vivo study

Additional file 1: Figure S1. OCT scan acquisition. Figure S2. Retinal layers visualized by OCT. Figure S3. Thickness of different retinal layers in WT and 3×Tg-AD mice at 4, 8, 12 and 16 months of age, based on in vivo OCT circle scans. Figure S4. Scotopic a-wave time to peak in WT and 3×Tg-AD mice, at 4, 8, 12 and 16 months of age, as response to several light stimuli. Figure S5. Linear regression fit to scotopic b-wave amplitude at 0.0095 cd.s/m2 and 9.49 cd.s/m2 in WT and 3×Tg-AD mice. Figure S6. OP1 time to peak values at 4, 8, 12 and 16 months of age, based on fERG analysis. Figure S7. Linear regression fit to base wave, first harmonic and second harmonic amplitudes and phases in WT and 3×Tg-AD mice. Figure S8. Spearman correlation between total retinal thickness and grey matter volume of the visual cortex, and photopic flicker response amplitude and grey matter volume of the visual cortex.