MOESM1 of Epigenetic therapy of novel tumour suppressor ZAR1 and its cancer biomarker function

Additional file 1: Figure S1. Overview ZAR1 genomic structure, expression pattern and GO-term correlation, Figure S2. ZAR1 promoter is hypermethylated across cancer cell lines. Figure S3. ZAR1 methylation in ovarian carcinoma. Figure S4. Epigenetic inactivation of ZAR1 across human cancers. Figure S5. ZAR1 is conserved across human, mouse, and xenopus with high C-terminal homology and structure prediction. Figure S6. Confirming human ZAR1 RNA binding ability. Figure S7. ZAR1 is cytosolic. Figure S8. Reexpression of ZAR1 alters the transcriptome and reveals association with mRNA 3′end processing. Figure S9. ZAR1 function depends on its zinc-finger. Figure S10. ZAR1 binding partner GO-term association overview. Figure S11. ZAR1 binding partner GO-term association overview. Figure S12. Targeting the ZAR1 genomic region with CRISPR ZAR1 guide RNA oligos. Figure S13. Effective epigenetic editing of ZAR1 with distinct RNA guide combinations upstream the TSS.