13058_2019_1220_MOESM1_ESM.pdf (11.18 MB)
MOESM1 of Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts
journal contribution
posted on 2019-11-30, 04:56 authored by Diane Lefley, Faith Howard, Fawaz Arshad, Steven Bradbury, Hannah Brown, Claudia Tulotta, Rachel Eyre, Denis Alférez, J. Wilkinson, Ingunn Holen, Robert Clarke, Penelope OttewellAdditional file 1: Figure S1. Spontaneous metastasis of T47D cells from mouse mammary ducts to human bone implants and mouse bone. Intra nipple injection of T47D cells into NOD SCID mice supplemented with 4 mg/L 17β oesteradiol results in tumour growth at the primary site. 8-weeks after resection of primary tumours metastases were detected in both human bone implants and mouse hind limbs.
