MOESM1 of Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

Additional file 1: Figure S1. Spontaneous metastasis of T47D cells from mouse mammary ducts to human bone implants and mouse bone. Intra nipple injection of T47D cells into NOD SCID mice supplemented with 4 mg/L 17β oesteradiol results in tumour growth at the primary site. 8-weeks after resection of primary tumours metastases were detected in both human bone implants and mouse hind limbs.