MOESM1 of Agreement between results of meta-analyses from case reports and clinical studies, regarding efficacy and safety of idursulfase therapy in patients with mucopolysaccharidosis type II (MPS-II). A new tool for evidence-based medicine in rare diseases

Additional file 1: Table S1. Search syntax used in different databases to gather the bibliographic data. Table S2. Case reports of males with MPS-II published prior to the bibliographic search of meta-analysis of clinical studies (January 2008 to December 2015). Table S3. Case reports of males with MPS-II published later to the bibliographic search of the meta-analysis of clinical studies (January 2016 to April 2018). Table S4. Agreement between the classification of outcomes based on the case report meta-analysis and the SOE classification based on the clinical study meta-analysis. Weak confirmatory method. Table S5. Sensitivity analysis on different futility boundaries. Figure S1. Agreement between the score of evidence from the case report meta-analysis and SOE from the clinical study meta-analysis. Weak confirmatory method.