MOESM11 of PD-L1 and PD-L2 expression correlated genes in non-small-cell lung cancer

Additional file 11: Fig. S3. Heat map analyses of PD-L1 and PD-L2 expression correlation gene signatures in TCGA datasets (LUAD and LUSC). A, B. Heat map analyses of mRNA expression Z-values in TCGA dataset LUSC A and LUAD B of gene signatures representing expression correlated genes with PD-L1 and PD-L2 across Lung_NSC, LUAD, and LUSC. Heat maps are sorted relative to the PD-L1 mRNA expression level (upper panels) or PD-L2 mRNA expression level (lower panels). Spearman and Pearson correlation coefficients r and corresponding P values for mRNA expression of signature genes and PD-L1 protein expression in LUAD (n = 365) and LUSC (n = 328) are shown to the right. C. Heat map analysis of mRNA expression Z-values for gene signatures representing genes expression correlated with PD-L1 (upper panel) and PD-L2 (lower panel) across LUAD and Lung_NSC. The heat map is sorted relative to PD-L1 mRNA expression level (upper panels) and PD-L2 mRNA expression level (lower panel). Spearman and Pearson correlation coefficients r and corresponding P values for mRNA expression of signature genes and PD-L1 protein expression in LUAD (n = 365) are shown to the right. Asterisks in the lower panel indicate genes also included in the analysis in the upper panel. Correlations assigned significant are shown in red. The criteria for significant expression correlation were Pearson correlation coefficient r ≥ 0.3 or ≤ − 0.3, Spearman correlation coefficient r ≥ 0.4 or ≤ − 0.4, and P values < 0.05. Abbreviations: IRF1cor, IRF1 expression correlated genes; Pe, Pearson; r, correlation coefficient; Sp, Spearman.