MOESM11 of A rapid passage through a two-active-X-chromosome state accompanies the switch of imprinted X-inactivation patterns in mouse trophoblast stem cells

Additional file 11: Summary of the metastable states of I-XCI in female TS cells observed in the present study. A. Table summarising the characteristics of the various TS cell populations observed in the study. B. We observe in the present study that undifferentiated TS cells spontaneously reactivate the paternal X partially or completely at a low frequency. Under specific environmental cues (including, in the case of the present study, the HAT selection) or mutation that either prevent XP inactivation or favour the expression of XP genes, TS cells carrying two active X chromosomes may undergo de novo inactivation of the maternal X.