Additional file 9: Figure S6. of The transcriptional and splicing landscape of intestinal organoids undergoing nutrient starvation or endoplasmic reticulum stress

Overview of proposed mechanism of splicing events upon metabolic stress. Various splicing/RNA processing genes contain PTC-containing exons flanked by DIs, which can undergo splicing events resulting in the transcript being targeted to NMD. These NMD targets are stabilized during stress. Genes that are specific during stress may undergo AS coupled to the usage of an out of frame alternative translation start site (aATG) rather than the canonical start site (cATG), resulting in an N-terminal protein variant. (PDF 172 kb)