13024_2018_261_MOESM8_ESM.pdf (280.16 kB)
Additional file 8: of Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model
journal contribution
posted on 2018-06-22, 05:00 authored by Lodewijk Toonen, Maurice Overzier, Melvin Evers, Leticia Leon, Sander van der Zeeuw, Hailiang Mei, Szymon Kielbasa, Jelle Goeman, Kristina Hettne, Olafur Magnusson, Marion Poirel, Alexandre Seyer, Peter ‘t Hoen, Willeke van Roon-MomFigure S6. principal component analysis (PCA) of measured metabolites. Individual barcodes of mice are depicted, plasma was obtained for each mouse at 3 time points A) Age is significantly correlated with PC1 (ρ = − 0.586, p < 0.05), hence explaining most of the variation between samples. SCA3 n = 4, wild-type (WT) n = 4. B) The third principal component (PC) is significantly correlated with genotype (ρ = − 0.463, p < 0.05). PC3 and PC4 are shown. (PDF 280 kb)
