Additional file 8: of Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

Figure S6. principal component analysis (PCA) of measured metabolites. Individual barcodes of mice are depicted, plasma was obtained for each mouse at 3 time points A) Age is significantly correlated with PC1 (ρ = − 0.586, p < 0.05), hence explaining most of the variation between samples. SCA3 n = 4, wild-type (WT) n = 4. B) The third principal component (PC) is significantly correlated with genotype (ρ = − 0.463, p < 0.05). PC3 and PC4 are shown. (PDF 280 kb)