Additional file 8: of Proteogenomic analysis of psoriasis reveals discordant and concordant changes in mRNA and protein abundance

Differentially expressed proteins previously identified by Ryu et al. [20]. Ryu et al. identified 36 proteins with significantly increased abundance in psoriasis lesions compared with normal skin. a The 36 proteins significantly enriched among the PP-increased proteins identified in our analysis (p = 0.033). Proteins we detected by LC-MS/MS were ranked in descending order according to the estimated PP/PN fold-change (horizontal axis; red, PP-increased; blue, PP-decreased). The cumulative overlap between the 36 proteins and this ranked protein list is shown. Yellow hash marks (top) denote placement of the 36 proteins relative to the ranked protein list from our analysis. b Association between SpC values in PP and PN skin for the 36 proteins (yellow symbols indicate DEPs). c LC-MS/MS-estimated fold changes for each of the 36 proteins (n = 14 patients; yellow bars indicate DEPs). d Twelve of the 36 proteins showing the strongest mRNA and protein increase. e Twelve of the 36 proteins showing the strongest mRNA and protein decrease. (TIFF 1598 kb)