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Additional file 8: of Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease

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posted on 2019-08-17, 04:26 authored by Sonia George, Nolwen Rey, Trevor Tyson, Corinne Esquibel, Lindsay Meyerdirk, Emily Schulz, Steven Pierce, Amanda Burmeister, Zachary Madaj, Jennifer Steiner, Martha Escobar Galvis, Lena Brundin, Patrik Brundin
Figure S8. Enrichment of inflammatory processes. a The 217 DE genes (significant and with a change of expression of at least 2) are plotted as protein nodes (199 total) with edges indicating confidence of interaction or similarity. A total of 726 biological process categories are significantly enriched among this set of proteins, the most significant based on 103 proteins annotated as “immune system process” in red and 78 proteins annotated as “defense response” in green. b A cluster of the interrelated GO annotations based on the 726 enriched processes. Node size indicates the number of genes and edges represent overlap of protein members between ontologies. Automatic grouping is indicated by the orange circles with text summarizing GO categories and text size indicating the number of significant categories. c Top enrichment categories based on GSEA comparing LPS and IL-4 treated mice and using the expression values (log2CPM) for the 15,938 mapped genes with a minimum average expression of 1 CPM in either LPS or IL-4 treated mice. CPM; counts per million, GO; gene ontology, GSEA; gene set enrichment. (TIF 104231 kb)

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