Additional file 8: of Maternal smoking and high BMI disrupt thyroid gland development

Figure S3. A. Correlations among TSH, cotinine, and T4 in the human fetal circulation. B. Correlation between fetal TSH and maternal BMI (continuous). C. Associations between smoking, maternal BMI, and fetal TSH levels in the female fetuses. In Ci-ii, the females were stratified according to smoke exposure and the effect of age and BMI (categorical) on TSH was examined. In Ciii-iv, TSH levels were correlated to BMI (continuous) in the control and smoke-exposed females. Pearson’s correlation P values in A, B, Ciii, and Civ are given within the graphs, including R2 values in the cases of statistically significance (P < 0.05). Arrowheads above the graphs indicate significant (P < 0.05) increase (▲) or decrease (▼). (PDF 451 kb)