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Additional file 8: of Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis
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posted on 2019-04-10, 05:00 authored by Terje Sundstrøm, Lars Prestegarden, Francisco Azuaje, Synnøve Aasen, Gro Røsland, Jobin Varughese, Marzieh Bahador, Simon Bernatz, Yannick Braun, Patrick Harter, Kai Skaftnesmo, Elizabeth Ingham, Lisa Mahakian, Sarah Tam, Clifford Tepper, Kjell Petersen, Katherine Ferrara, Karl Tronstad, Morten Lund-Johansen, Rudi Beschorner, Rolf Bjerkvig, Frits ThorsenFigure S7. a Functional classification of the brain metastasis gene signature. Human biological processes (metabolic processes are highlighted in red), and b signaling pathways associated with the 108-gene brain metastasis signature using the Protein Analysis Through Evolutionary Relationships (PANTHER) classification system. c Known and predicted protein interactions of β-sitosterol from the Search Tool for Interactions of Chemicals (STITCH 4.0). Green lines represent direct interactions with β-sitosterol whereas blue lines represent protein-protein interactions. Direct activation (green arrows) or inhibition (red lines) is indicated. d Significant statistical associations of β-sitosterol targets with cellular processes predicted with the Human Experimental/Functional Mapper (HEFalMp). P-values represent approximate multiple hypothesis corrected values. (TIF 1333 kb)
