Additional file 8 of Improved homology modeling of the human & rat EP4 prostanoid receptors

: Figure S8. Homology model of the hEP4 receptor docked with PGE2. All 5 poses output from an induced fit protocol are shown [45, 53–56] . PGE2 is displayed in ball and stick representation with non-polar hydrogens hidden (gray). Dotted lines indicate hydrogen bonding interactions. hEP4-PGE2 interactions include: (1) The alpha chain carboxylate to both Y80(2.65), and R316(7.40) (2) The 11-hydroxyl to the OH group of S69(2.54) (3) The carbonyl oxygen/T76(2.61) and (4) The 15-hydroxyl to D65(2.50) is 4.3 Å and within proximity to the hEP4 backbone. NOTE: This figure is part of the addendum and added to the original manuscript on March 29th, 2019. All other sections of this report were prepared prior to December 5th, 2018 release of EP4 crystal structure. (PNG 451 kb)