Additional file 8: Figure S3. of SABRE: a method for assessing the stability of gene modules in complex tissues and subject populations

Random module stability. To get a sense of the stability that could be expected of a module containing genes with minimal relation to each other, a simulation study was carried out. Modules of size 50, 100, 150, 200, 250, 300, 350, and 400 were randomly assembled by sampling from the all 2512 gene symbols in the filtered dataset. This was done 100 times for each size of module. For each random module, their best match Jaccard similarity ceofficients were computed for each of the 1000 bootstrap results previously generated, and the resulting distribution was summarized using the h-index. (PNG 51 kb)