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Additional file 7: of PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy
figure
posted on 2017-05-12, 05:00 authored by Iris Salaroglio, Elisa Panada, Enrico Moiso, Ilaria Buondonno, Paolo Provero, Menachem Rubinstein, Joanna Kopecka, Chiara RigantiMRP1 expression on cell surface of sensitive and resistant colon cancer cells upon PERK/Nrf2 inhibition. a, b. Representative flow cytometry histograms of MRP1 protein in human chemoresistant colon cancer HT29/MDR cells and ER stress-resistant clones (HT29/Tg, HT29/Tun, HT29/Bfa), stably and inducibly transduced with a silencing vector for PERK, or treated with PD98059 (10 μM, 72 h), which blocks Nrf2 nuclear translocation. HT29 were included as control of chemosensitive/ER stress-sensitive cells. Grey peaks: non immune isotypic antibody. (TIF 1205 kb)
