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Additional file 7: of M6A-mediated upregulation of LINC00958 increases lipogenesis and acts as a nanotherapeutic target in hepatocellular carcinoma

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posted on 09.01.2020 by Xueliang Zuo, Zhiqiang Chen, Wen Gao, Yao Zhang, Jinguo Wang, Junfeng Wang, Ming Cao, Juan Cai, Jindao Wu, Xuehao Wang
Figure S3. LINC00958 exerts its tumor-promoting effects via miR-3619-5p. (A) The efficiency of miR-3619-5p mimics in LINC00958-overexpressed Hep3B cells was confirmed using RT-qPCR. (B) CCK-8 assays were conducted to evaluate the effects of miR-3619-5p overexpression on the proliferative ability of LINC00958-overexpressed Hep3B cells. The data are shown as the mean ± SEM. *P < 0.05, **P < 0.01 vs. the NC group. (C) EdU assays were performed to analyze the effects of miR-3619-5p overexpression on LINC00958-overexpressed Hep3B cells. The data are shown as the mean ± SEM. **P < 0.01 vs. the NC group. (D) Transwell assays were conducted to evaluate the effects of miR-3619-5p overexpression on the migration and invasion of LINC00958-overexpressed Hep3B cells. The data are shown as the mean ± SEM. ***P < 0.001 vs. the NC group.

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National Natural Science Foundation of China

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