Additional file 7: of Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of cMYC-IRF4-miR-125b interplay

(A, B) Treatment with the indicated concentrations of JQ1 (48 h) represses IRF4 and upregulates MICA mRNA expression in SKO-007(J3) cells. Data of real-time PCR analysis, expressed as fold change units, were normalized with GAPDH and referred to the untreated cells considered as calibrator. Data represent the mean of three experiments (*P < 0.05). (TIF 2956 kb)