13045_2016_362_MOESM7_ESM.tif (2.89 MB)
Additional file 7: of Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of cMYC-IRF4-miR-125b interplay
figure
posted on 2016-12-01, 05:00 authored by Maria Pia Abruzzese, Maria Bilotta, Cinzia Fionda, Alessandra Zingoni, Alessandra Soriani, Elisabetta Vulpis, Cristiana Borrelli, Beatrice Zitti, Maria Petrucci, Maria Ricciardi, Rosa Molfetta, Rossella Paolini, Angela Santoni, Marco Cippitelli(A, B) Treatment with the indicated concentrations of JQ1 (48 h) represses IRF4 and upregulates MICA mRNA expression in SKO-007(J3) cells. Data of real-time PCR analysis, expressed as fold change units, were normalized with GAPDH and referred to the untreated cells considered as calibrator. Data represent the mean of three experiments (*P < 0.05). (TIF 2956 kb)
