Additional file 7 of Influenza vaccination in early Alzheimer’s disease rescues amyloidosis and ameliorates cognitive deficits in APP/PS1 mice by inhibiting regulatory T cells

Additional file 7: Figure S7. No effect of ATRA on cognitive function in APP/PS1 animals. (A) MWM analysis of the escape latency (A) of the WT+Vehicle (n = 6), WT+ATRA (n = 6), AD+Vehicle (n = 6) and AD+ATRA mice (n = 6) (mean ± SEM, two-way repeated-measures ANOVA and LSD post hoc test, *P < 0.05, **P < 0.01, ***P < 0.001) during the acquisition phase. (B-D) Average numbers of platform crossings (C), percentage of time and distance spent (D) in the target quadrant in each group and their representative traces (B) during the spatial probe phase (n = 6) (mean±SEM, one-way ANOVA and LSD post hoc analysis; *P < 0.05, **P < 0.01).