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Additional file 7 of Improved homology modeling of the human & rat EP4 prostanoid receptors

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posted on 2019-08-28, 04:07 authored by Melissa Holt, Chi Ho, M. Morano, Stephen Barrett, Adam Stein
: Figure S7. Alignment of PGE2 docked to hEP4 with Crystal structure of the prostaglandin D2 receptor CRTH2 with fevipeprant. Top down view of receptor with transmembrane helices numbered. hEP4 receptor is display in rainbow coloring. DP2 receptor is shown in teal. Key residues for predicted hEP4 agonist binding site are shown with the corresponding DP2 residues overlaid. C(S/W) xP motif overlays between models with W of the CWxP motif overlaying with S285(6.48). D65(2.50) overlays well between the models. S103(3.41) of the hEP4 structure is closely positioned to either a S118 or M115 residue of DP2 receptor. (PNG 1136 kb)

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