Additional file 7: of Identification of sequence variants associated with severe microtia-astresia by targeted sequencing

Figure S3. Predicted secondary structures of the wild and mutant protein sequences flanking the remaining candidate rare mutations. The diagrams show the protein sequences with their secondary structures and their confidence values at the aligned positions. The secondary structure is annotated as follows: pink cylinder (alpha-helix); yellow arrow (beta-sheet); black line (coil); Conf, confidence; Pred, predict; H in Pred line (Helix); C in Pred line (coil); E in Pred line (sheet); AA, amino acid;↑, mutant amino acid. (PDF 1140 kb)