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Additional file 7: Figure S7. of MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib
figure
posted on 2016-12-08, 05:00 authored by Adelaide I. J. Young, Andrew Law, Lesley Castillo, Sabrina Chong, Hayley Cullen, Martin Koehler, Sebastian Herzog, Tilman Brummer, Erinna Lee, Walter Fairlie, Morghan Lucas, David Herrmann, Amr Allam, Paul Timpson, D. Watkins, Ewan Millar, Sandra OâToole, David Gallego-Ortega, Christopher Ormandy, Samantha Oakesshowing that MCL-1 antagonism increased sensitivity to anoikis in MDA-MB-468-2A but not MDA-MB-231-2A cells. Bar graphs depicting the average fraction of apoptotic cells (total Annexin V-positive by flow cytometry) in MDA-MB-468-2A (A) and MDA-MB-231-2A (B) plated as monolayers in culture (normal) or onto PolyHEMA treated plates and harvested at 24Â hours after plating. ANOVA p value, dashes indicate statistically significant groups. Bars indicate statistically significant groups, p value paired t tests. (JPG 409Â kb)