Additional file 6: of Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis
journal contributionposted on 01.06.2018 by Tatyana Shelkovnikova, Michail Kukharsky, Haiyan An, Pasquale Dimasi, Svetlana Alexeeva, Osman Shabir, Paul Heath, Vladimir Buchman
Any type of content formally published in an academic journal, usually following a peer-review process.
Figure S6. Dose-dependent toxicity of enoxacin, edaravone and riluzole. a SH-SY5Y cells were treated with corresponding doses of compounds for 24 h, and toxicity was assessed using CellTiter Blue® Cell Viability Assay. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 as compared to control (non-treated) cells (Kruskal-Wallis test with Dunn’s correction for multiple comparisons). b Enoxacin enhances paraspeckle assembly both with short (4 h) and prolonged (24 h) treatment at a non-toxic concentration of 50 μM. Representative images are shown. (DOCX 298 kb)