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Additional file 6: of Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis

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posted on 01.06.2018 by Tatyana Shelkovnikova, Michail Kukharsky, Haiyan An, Pasquale Dimasi, Svetlana Alexeeva, Osman Shabir, Paul Heath, Vladimir Buchman
Figure S6. Dose-dependent toxicity of enoxacin, edaravone and riluzole. a SH-SY5Y cells were treated with corresponding doses of compounds for 24 h, and toxicity was assessed using CellTiter Blue® Cell Viability Assay. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 as compared to control (non-treated) cells (Kruskal-Wallis test with Dunn’s correction for multiple comparisons). b Enoxacin enhances paraspeckle assembly both with short (4 h) and prolonged (24 h) treatment at a non-toxic concentration of 50 μM. Representative images are shown. (DOCX 298 kb)

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