Additional file 6: of “Omics” data integration and functional analyses link Enoyl-CoA hydratase, short chain 1 to drug refractory dilated cardiomyopathy

Figure S5. Proposed schematic: Dysfunction in the mitochondria. Legend: Arrows (red) pointing up represent up-regulated genes and arrows (green) pointing down, down-regulated genes. Printed in blue indicates putative modifiers and in red mutations. In bold print indicates genes carrying a variant. Orange arrows indicate the flow of catalysis in the fatty acid beta-oxidation pathway. Green arrows show the flow of catalysis in the Leucine degradation 1 pathway. Purple arrows show the flow of catalysis in the Valine degradation 1 pathway. Blue arrows indicate the flow of catalysis in the Isoleucine degradation 1 pathway. In boxes at the end of each pathway are proposed products of each pathway. (PPTX 583 kb)