Additional file 6: of MICA immune complex formed with alpha 3 domain-specific antibody activates human NK cells in a Fc-dependent manner

Figure S6. MICA antibodies induce ADCC. C1R-MICA*002 cell line ADCC experiment was conducted by co-culturing C1R-MICA*002 cell line with primary NK cells (10 to 1 effector to target ratio) in the presence of 10 μg/mL control hIgG1 or anti-MICA antibodies, 6E1, 5E10 or 7G10 for 4 h, the data is the average of 3 technical replicates with error bar representing SD, and the dataset is a representative of 3 independent experiments with p-values generated from unpaired t-test. *p > = 0.05; **p < 0.05. (JPG 95 kb)