13073_2017_404_MOESM6_ESM.pdf (55.57 kB)
Additional file 6: of A functional SNP associated with atopic dermatitis controls cell type-specific methylation of the VSTM1 gene locus
journal contribution
posted on 2017-02-20, 05:00 authored by Dilip Kumar, Kia Puan, Anand Andiappan, Bernett Lee, Geertje Westerlaken, Doreen Haase, Rossella Melchiotti, Zhuang Li, Nurhashikin Yusof, Josephine Lum, Geraldine Koh, Shihui Foo, Joe Yeong, Alexessander Alves, Juha Pekkanen, Liang Sun, Astrid Irwanto, Benjamin Fairfax, Vivek Naranbhai, John Common, Mark Tang, Chin Chuang, Marjo-Riitta Jarvelin, Julian Knight, Xuejun Zhang, Fook Chew, Shyam Prabhakar, Liu Jianjun, De Yun Wang, Francesca Zolezzi, Michael Poidinger, E. Lane, Linde Meyaard, Olaf RĂśtzschkeIn silico prediction of transcription factors with allele-specific binding to rs612529. The web based prediction tools JASPAR (A) and TRANSFAC (B) were used to identify potential transcription factor binding sites in the VSTM1 promoter region affected by the allelic variations of rs612529 T/C. Only sites predicted with a binding score greater than 5.0 (JASPAR) and 0.9 (TRANSFAC) were selected for further analysis. The nucleotide underlined in red indicates the location of rs612529 within binding motif of the respective TF. Yellow shaded rows indicate transcription factors predicted to be highly specific for T allele.5. (PDF 55Â kb)
